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Clinical Pharmacology in Psychiatry

Bridging the Experimental—Therapeutic Gap

  • Book
  • © 1983

Overview

Editors:
  1. Lars F. Gram

    1. Department of Clinical Pharmacology, Odense University, School of Medicine, Odense, Denmark

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  2. Earl Usdin

    1. Department of Psychiatry and Human Behavior, University of California, Irvine, USA

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  3. Svein G. Dahl

    1. Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Tromsø, Norway

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  4. Per Kragh-Sørensen

    1. Department of Psychiatry, Odense University, School of Medicine, Odense, Denmark

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  5. Folke Sjöqvist

    1. Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden

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  6. Paolo L. Morselli

    1. L.E.R.S. Sythélabo, Paris, France

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Utilization of Psychotropic Drugs: Geographical and Cultural Determinants and Relationship to Morbidity

    1. Front Matter

      Pages 1-1
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    2. Utilization of psychotropic drugs in Sweden and the other Nordic countries

      • Ulf Bergman, Ingegerd Agenäs, Monica Dahlström
      Pages 3-17

    3. Patterns of use of psychotropic drugs in Spain in an international perspective

      • Joan-Ramon Laporte, Dolors Capellà, Miquel Porta, María Elisa Frati
      Pages 18-31

    4. Heavy drug use among the elderly: prescription surveys in Manitoba

      • P. A. Mitenko, D. S. Sitar, F. Y. Aoki
      Pages 32-41

    5. To what extent are inter- and intraregional differences in psychotropic drug use explained by demographic and socioeconomic factors?

      • David J. King, Kathryn Griffiths
      Pages 42-58

  3. Methodology of Clinical Trials in Psychopharmacology

    1. Front Matter

      Pages 59-59
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    2. Methodology of clinical trials: current issues

      • Bernard J. Carroll
      Pages 61-67

    3. Practical aspects of the utilization of double-blind trials using adjusted doses of psychotropic drugs

      • Pierre Simon, Laurence Landragin, Alain J. Puech, Yves Lecrubier
      Pages 68-73

    4. Improving reliability and validity of adverse drug reaction assessment in psychopharmacology

      • E. M. Sellers, C. A. Naranjo, U. Busto
      Pages 74-82

    5. Clinical evaluation of the cardiac effects of new psychotropic drugs

      • Graham D. Burrows, Trevor R. Norman, Jitu Vohra, Graeme Sloman
      Pages 83-98

    6. The implications of left ventricular performance for tricyclic antidepressant drug treatment

      • Alexander H. Glassman, Steven P. Roose, B. Timothy Walsh, Thomas Cooper, Elsa V. Giardina, J. T. Bigger Jr
      Pages 99-107

    7. Registration of antidepressant drugs — views of a regulatory agency

      • Kjell Strandberg
      Pages 108-113

    8. Phase-4 studies in psychopharmacology — new antidepressant drugs

      • P. Kragh-Sørensen, P. Christensen, L. F. Gram, C. B. Kristensen, M. Møller, O. L. Pedersen et al.
      Pages 114-126

  4. Clinical Pharmacokinetics of Neuroleptics

    1. Front Matter

      Pages 127-127
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    2. Overview: measuring plasma concentrations of psychotherapeutic drugs

      • Leo E. Hollister
      Pages 129-135

    3. Possible role of hydroxymetabolites in the action of neuroleptics

      • Svein G. Dahl, Petter-Arnt Hals, Helge Johnsen, Eliane Morel, Kenneth G. Lloyd
      Pages 136-149

    4. Radioreceptor assay for measurement of anticholinergic drugs in serum

      • Joseph T. Coyle, Larry E. Tune
      Pages 150-164

    5. Clinical effects related to the serum concentrations of thioridazine and its metabolites

      • Rolf Axelsson, Erik Mårtensson
      Pages 165-174

    6. Plasma levels of perphenazine related to clinical effect and extrapyramidal side-effects

      • Lars Bolvig Hansen, Niels-Erik Larsen
      Pages 175-181
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Keywords

Editors and Affiliations

  • Department of Clinical Pharmacology, Odense University, School of Medicine, Odense, Denmark

    Lars F. Gram

  • Department of Psychiatry and Human Behavior, University of California, Irvine, USA

    Earl Usdin

  • Department of Pharmacology, Institute of Medical Biology, University of Tromsø, Tromsø, Norway

    Svein G. Dahl

  • Department of Psychiatry, Odense University, School of Medicine, Odense, Denmark

    Per Kragh-Sørensen

  • Department of Clinical Pharmacology, Karolinska Institute, Huddinge University Hospital, Sweden

    Folke Sjöqvist

  • L.E.R.S. Sythélabo, Paris, France

    Paolo L. Morselli

Bibliographic Information

  • Book Title: Clinical Pharmacology in Psychiatry

  • Book Subtitle: Bridging the Experimental—Therapeutic Gap

  • Editors: Lars F. Gram, Earl Usdin, Svein G. Dahl, Per Kragh-Sørensen, Folke Sjöqvist, Paolo L. Morselli

  • DOI: https://doi.org/10.1007/978-1-349-06671-1

  • Publisher: Palgrave Macmillan London

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The contributors 1983

  • Softcover ISBN: 978-1-349-06673-5Published: 01 January 1983

  • eBook ISBN: 978-1-349-06671-1Published: 18 June 1983

  • Edition Number: 1

  • Number of Pages: XVIII, 413

  • Topics: Pharmacology/Toxicology, Psychiatry

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