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Molecular Mechanisms in Muscular Contraction

  • Textbook
  • © 1990

Overview

Editors:
  1. John M. Squire

    1. Imperial College of Science, Technology and Medicine, London, UK

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Part of the book series: Topics in Molecular and Structural Biology (TMSB)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xii
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  2. Organisation and Properties of the Striated Muscle Sarcomere

    • John M. Squire, Pradeep K. Luther, Edward P. Morris
    Pages 1-48

  3. The Nature of the Actin Molecule

    • Clarence E. Schutt, Uno Lindberg
    Pages 49-63

  4. The Structure of F-actin Calculated from X-ray Fibre Diagrams and the 0.6 nm Crystal Structure

    • K. C. Holmes, D. Popp, W. Gebhard, W. Kabsch
    Pages 65-75

  5. Muscle Mechanics and Biochemical Kinetics

    • Bernhard Brenner
    Pages 77-149

  6. Crossbridge Patterns in Defined Static States in Insect Asynchronous Flight Muscle

    • Mary C. Reedy, Michael K. Reedy, Kenneth A. Taylor
    Pages 151-170

  7. Nuclear Magnetic Resonance Studies of Calcium-modulated Proteins and Actin-Myosin Interaction

    • B. A. Levine, A. J. G. Moir, I. P. Trayer, R. J. P. Williams
    Pages 171-209

  8. Crossbridge Movements Monitored by Extrinsic Probes

    • Thomas P. Burghardt, Katalin Ajtai
    Pages 211-239

  9. Functional Aspects of the Myosin Rod in Contraction

    • William F. Harrington, Michael E. Rodgers, Julien S. Davis
    Pages 241-263

  10. Equatorial X-ray Diffraction Studies of Single Skinned Muscle Fibres

    • Leepo C. Yu, Richard J. Podolsky
    Pages 265-286

  11. Static and Time-resolved X-ray Diffraction Studies of Fish Muscle

    • Jeff Harford, John M. Squire
    Pages 287-320

  12. Back Matter

    Pages 321-327
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Keywords

About this book

Muscle cells provide a unique probe into the motile properties of all living systems. A full understanding of the molecular mechanisms within muscle cells is therefore important to many areas of biological research. It is now nearly 40 years since the postulation of the sliding filament model of muscle contraction yet only recently has sufficient evidence been produced to support a convincing model. This book marks a turning point in muscle research. It reviews the evidence that myosin cross-bridges do indeed swing on actin filaments during contraction, and starts to tackle the problems this raises: what are the geometrics of the attached states of cross-bridges on actin? How many states are there? What is the sequence of molecular events during muscle activation? And is the primary source of muscular force cross-bridge swinging or Helix-coil transition?

Editors and Affiliations

  • Imperial College of Science, Technology and Medicine, London, UK

    John M. Squire

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