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Oligodeoxynucleotides

Antisense Inhibitors of Gene Expression

  • Textbook
  • © 1989

Overview

Editors:
  1. Jack S. Cohen

    1. National Cancer Institute, National Institutes of Health, Bethesda, USA

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Part of the book series: Topics in Molecular and Structural Biology (TMSB)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Introduction: Strategies and Realities

    • Jack S. Cohen
    Pages 1-6

  3. Synthesis of Oligonucleotides and Oligonucleotide Analogues

    • Marvin H. Caruthers
    Pages 7-24

  4. Oligodeoxynucleotides Covalently Linked to Intercalating and Reactive Substances: Synthesis, Characterization and Physicochemical Studies

    • Nguyen Thanh Thuong, Ulysse Asseline, Thérèse Montenay-Garestier
    Pages 25-51

  5. Inhibition of Gene Expression by Oligonucleotides

    • John Goodchild
    Pages 53-77

  6. Non-ionic Antisense Oligonucleotides

    • Paul S. Miller
    Pages 79-95

  7. Phosphorothioate Oligodeoxynucleotide Analogues

    • C. A. Stein, Jack S. Cohen
    Pages 97-117

  8. α-Oligodeoxynucleotide Analogues

    • B. Rayner, C. Malvy, J. Paoletti, B. Lebleu, C. Paoletti, J.-L. Imbach
    Pages 119-136

  9. Control of Gene Expression by Oligodeoxynucleotides Covalently Linked to Intercalating Agents and Nucleic Acid-cleaving Reagents

    • Claude Hélène, Jean-Jacques Toulmé
    Pages 137-172

  10. Oligonucleotides Linked to Reactive Groups

    • D. G. Knorre, V. V. Vlassov, V. F. Zarytova
    Pages 173-196

  11. Oligonucleotide Recognition of Double-helical DNA by Triple-helix Formation

    • Peter B. Dervan
    Pages 197-210

  12. Antisense Oligodeoxynucleotides as a Tool for Studying Cell Regulation: Mechanism of Uptake and Application to the Study of Oncogene Function

    • L. M. Neckers
    Pages 211-231

  13. Pharmaceutical Considerations

    • Gerald Zon
    Pages 233-247

  14. Back Matter

    Pages 249-255
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Keywords

About this book

This first-ever book on oligodeoxynucleotides describes in detail the new antisense approach to chemotherapy. It is written by world experts, covers all areas of current knowledge and includes new results. The principle of the antisense approach is that an antisense mRNA base sequence will bind to its target mRNA base sequence and thus bring about the selective inhibition of gene expression. The antisense approach is important in general in understanding gene function, and more specifically as a potential basis for new drugs, notably against cancer and viral genes.

Editors and Affiliations

  • National Cancer Institute, National Institutes of Health, Bethesda, USA

    Jack S. Cohen

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