Therapeutic Monoclonal Antibodies

1. Front Matter

   Pages i-xiii

   PDF

2. The Use of In Vitro Immunization, Cloning of Variable Regions, and SCID Mice for the Production of Human Monoclonal Antibodies

   • Carl A. K. Borrebaeck, Lena Danielsson, Mats Ohlin, Jonas Carlsson, Roland Carlsson

   Pages 1-15

3. Construction of Recombinant Therapeutic Monoclonal Antibodies

   • James W. Larrick, Jorge V. Gavilondo, Maria J. Coloma, Kirk E. Fry

   Pages 17-34

4. Antibody-Mediated Cancer Diagnosis and Therapy

   • Jenny M. Bator, Christopher L. Reading

   Pages 35-56

5. Current Status and Future Perspectives of Chemoimmunoconjugates for the Treatment of Cancer

   • Ralph A. Reisfeld, Martin Schrappe

   Pages 57-73

6. Gangliosides as Targets for Monoclonal Antibody Therapy of Cancer

   • Reiko F. Irie, Mepur H. Ravindranath

   Pages 75-94

7. Mouse Antibodies to Carcinomas

   • Karl Erik Hellström, Ingegerd Hellström

   Pages 95-108

8. Therapeutic Implication of Monoclonal Antibodies against Multidrug-Resistant Tumor Cells

   • Takashi Tsuruo, Hirofumi Hamada

   Pages 109-126

9. Radioimmunotherapy with 90Yttrium—Anti-Idiotype Monoclonal Antibody

   • Barbara A. Parker, Samuel E. Halpern, Ivor Royston

   Pages 127-141

10. Immunoconjugates of a Protein Synthesis-Inhibiting Drug

    • Alton C. Morgan Jr., F. Taha Comezoglu, Ron Manger, Bruce B. Jarvis, Paul G. Abrams, Gowsala Sivam

    Pages 143-158

11. Human Monoclonal Anti-Idiotypic Antibodies against a Murine Monoclonal Antibody (Mab17-1A) as an Anti-Tumor Vaccine

    • Michael Steinitz, Sara Tamir, Jan-Erik Frödin, Håkan Mellstedt

    Pages 159-171

12. Uses of Human Monoclonal Antibodies to Human Cytomegalovirus and Varicella-Zoster Virus

    • Steven K. H. Foung, Peggy A. Bradshaw, David Emanuel

    Pages 173-185

13. Development of a Human Monoclonal Antibody against Cytomegalovirus with the Aim of a Passive Immunotherapy

    • Yasuhiko Masuho, Yoh-Ichi Matsumoto, Tohru Sugano, Takami Tomiyama, Satoshi Sasaki, Tamotsu Koyama

    Pages 187-207

14. Characterization of Human Anti-Cytomegalovirus Monoclonal Antibodies

    • Paul H. Ehrlich, Lars Östberg

    Pages 209-222

15. Immunoprotective Capacities of Human and Murine Monoclonal Antibodies Recognizing Serotype-Specific and Common Determinants of Gram-negative Bacteria

    • Alois B. Lang, Urs Bruderer, Emil Fuerer, James W. Larrick, Stanley J. Cryz Jr.

    Pages 223-234

16. Preclinical Development of Xomen™-E5

    • Ada H. C. Kung, Elizabeth A. Saria, Nancy Wedel, Patrick W. Trown

    Pages 235-251

17. Randomized Placebo-controlled Study of E5 Monoclonal Antiendotoxin Antibody

    • Kenneth Gorelick, Patrick J. Scannon, John Hannigan, Nancy Wedel, Samuel K. Ackerman

    Pages 253-261

18. Human Monoclonal Antibodies against Human Red Blood Cells

    • Phillippe Rouger, D. Goossens

    Pages 263-286

19. CD7 Monoclonal Antibodies

    • Peter Amlot, Salvatore Cammisuli

    Pages 287-302

20. Large-Scale Production of Monoclonal Antibodies

    • Cristina Glad, Inge Nilsson

    Pages 303-319

A review of therapeutic antibodies which have commercial potential. It discusses PCR cloning of Igs, immortalization by gene transfer, scale up production, infectious diseases, viruses, bacteria, parisites, inflammation/immunology, blood grouping, cells, cytokines, tumours and MDR.

• antibody
• bacteria
• blood
• cytokine
• diseases
• immunization
• immunology
• immunotherapy
• infectious
• infectious disease
• infectious diseases
• inflammation
• kinetics
• research
• vaccine
• antibodies

Policies and ethics