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Retroviral Proteases

Control of maturation and morphogenesis

  • Textbook
  • © 1990

Overview

Editors:
  1. Laurence H. Pearl

    1. Department of Biochemistry, University College, London, UK

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction

    • Laurence H. Pearl
    Pages 1-3

  3. Characterisation and Inhibition of the Retroviral HIV-Protease

    • Klaus von der Helm, S. Seelmeir, U. Junker
    Pages 5-8

  4. The HIV-1 Aspartyl Protease: Maturation and Substrate Specificity

    • Christine Debouck, Ingrid C. Deckman, Stephan K. Grant, Robert J. Craig, Michael L. Moore
    Pages 9-17

  5. Cleavage of RT/RNase H by HIV-1 Protease and Analysis of Substrate Cleavage Sites in vitro

    • K. Moelling, M. Nawrath, T. Schulze, L. Pavlitzkova, M. Soucek, K.-H. Budt et al.
    Pages 19-29

  6. Retroviral Protease: Substrate Specificity and Inhibitors

    • Yoshiyuki Yoshinaka, Iyoko Katoh, Kohei Oda
    Pages 31-39

  7. HIV pol Expression via a Ribosomal Frameshift

    • Alan J. Kingsman, Wilma Wilson, Susan M. Kingsman
    Pages 41-53

  8. Functional Characterisation of HIV-1 gag-pol Fusion Protein

    • Cheng Peng, Karin Moelling, Nancy T. Chang, Tse Wen Chang
    Pages 55-62

  9. Biosynthesis and Processing of the gag and pol Polyproteins of Human Immunodeficiency Virus Type 1 in Escherichia coli

    • Mei-Huei T. Lai, Albert G. Dee, Peter H. Zervos, William F. Heath Jr, Maurice E. Scheetz
    Pages 63-71

  10. Dimerisation of the HIV-1 Protease: Preliminary Analysis Using Gel Permeation Chromatography

    • O. M. P. Singh, E. M. J. Roud Mayne, M. P. Weir
    Pages 73-78

  11. Three-dimensional Structure and Evolution of HIV-1 Protease

    • Andrew Wilderspin, Duncan Gaskin, Risto Lapatto, Tom Blundell, Andrew Hemmings, John Overington et al.
    Pages 79-91

  12. X-Ray Analysis of HIV-1 Protease and Its Complexes with Inhibitors

    • Maria Miller, Amy L. Swain, Mariusz Jaskólski, Bangalore K. Sathyanarayana, Garland R. Marshall, Daniel Rich et al.
    Pages 93-106

  13. Expression of HIV-1 gag and pol Gene Products using Recombinant Baculoviruses

    • Helen R. Mills, Hilary A. Overton, Ian M. Jones
    Pages 107-115

  14. Morphogenesis of Retroviruses: A Complex Role for the Matrix (MA) Protein in Assembly, Stability and Intracellular Transport of Capsid Proteins

    • Sung Rhee, Eric Hunter
    Pages 117-129

  15. The Action of Retroviral Protease in Various Phases of Virus Replication

    • M. M. Roberts, S. Oroszlan
    Pages 131-139

  16. Terminal Stages of Retrovirus Morphogenesis

    • Ronald Luftig, Kazuyoshi Ikuta, Ming Bu, Peter Calkins
    Pages 141-148

  17. Analysis of the Assembly of the HIV Core by Electron Microscope Tomography

    • Stefan Höglund, Lars-Göran Öfverstedt, Ã…sa Nilsson, Muhsin Özel, Thorsten Winkel, Ulf Skoglund et al.
    Pages 149-157

  18. Morphogenesis, Maturation and Fine Structure of Lentiviruses

    • Hans R. Gelderblom, Preston A. Marx, Muhsin Özel, Dirk Gheysen, Robert J. Munn, Kenneth I. Joy et al.
    Pages 159-180

  19. Back Matter

    Pages 181-183
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Keywords

About this book

This volume describes the state-of-the-art of our understanding of the structure and function of retroviral proteases, and their substrates, the viral polyproteins, described by the leading workers in the field. The contributions range from detailed biochemical and structural characterisation of several retroviral proteases including that from HIV-1, through the analysis of the proteolytic processing of the viral polyproteins, to the structure of the viral capsids formed by the action of the protease, and is essential reading for anyone interested in the molecular biology of AIDS.

Editors and Affiliations

  • Department of Biochemistry, University College, London, UK

    Laurence H. Pearl

Bibliographic Information

  • Book Title: Retroviral Proteases

  • Book Subtitle: Control of maturation and morphogenesis

  • Editors: Laurence H. Pearl

  • DOI: https://doi.org/10.1007/978-1-349-11907-3

  • Publisher: Red Globe Press London

  • eBook Packages: Engineering, Engineering (R0)

  • Copyright Information: Macmillan Publishers Limited 1990

  • Edition Number: 1

  • Number of Pages: XI, 183

  • Additional Information: Previously published under the imprint Palgrave

  • Topics: Molecular Medicine, Cell Biology

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