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Animals and Alternatives in Toxicology

Present Status and Future Prospects

  • Textbook
  • © 1991

Overview

Editors:
  1. Michael Balls

    1. University of Nottingham, UK

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  2. James Bridges

    1. University of Surrey, Guildford, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. Jacqueline Southee

    1. FRAME, Nottingham, UK

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiii
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  2. The Future for Acute Oral Toxicity Testing

    • David G. Clark, Robin Fielder, Clive Joseph, John Gardner, Maurice Smith
    Pages 1-21

  3. The Current Status of Non-animal Alternative Methods in Skin and Eye Irritancy Testing

    • Dennis W. Swanston, J. Gordon Black, Paul A. Duffy, Mark A. Pemberton
    Pages 23-51

  4. Chronic Toxicity Testing: Present Perspectives and the Way toward Shorter Screening, Decreased Use of Resources and Better Risk Assessment

    • Peter H. Bach, Andrew Cockburn, David J. Esdaile, Paul Grasso, Cyndy E. Lumley
    Pages 53-89

  5. Genotoxicity Testing

    • R. Colin Garner
    Pages 91-120

  6. Alternative Methods and Their Application in Neurotoxicity Testing

    • Christopher K. Atterwill, Michael G. Simpson, Richard J. Evans, Sandra L. Allen, David Ray
    Pages 121-152

  7. Immunotoxicology and Allergy: Options for Ex Vivo and In Vitro Experimentation

    • Philip A. Botham, Ian Kimber
    Pages 153-176

  8. The Future of Alternative Approaches in Reproductive Toxicity Testing

    • Paul Duffy, Stuart Freeman, Derek Newall
    Pages 177-199

  9. Toxicity Data Derived from Man

    • Glyn Volans, Peter Blain, Peter Bennett, Colin Berry, Jenny Sims, Steven Warrington
    Pages 201-221

  10. Ecotoxicology

    • Colin H. Walker, Peter W. Greig-Smith, Norman O. Crossland, Richard Brown
    Pages 223-251

  11. Computer Modelling and Information Technology

    • David Bawden, Michael S. Tute, John C. Dearden
    Pages 253-289

  12. The Development, Validation and Acceptance of In Vitro Toxicity Tests

    • Michael Balls, Christoph A. Reinhardt, Horst Spielmann, Erik Walum
    Pages 291-312

  13. Future Developments in In Vitro Methodology

    • Michael Balls, Michael Garle, Richard Clothier
    Pages 313-339

  14. Concluding Remarks

    • André McLean
    Pages 341-344

  15. Back Matter

    Pages 345-390
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Keywords

About this book

This volume considers the second report of the FRAME Toxicity Committee presenting reviews and discussions by invited authors and general discussions. It covers developments in toxicology and the use of non-animal methods in toxicity testing since the first report, published in 1983; it highlights the need for rationalisation and harmonisation of regulatory guidelines for more critical attitudes toward currently accepted animal tests and for more attention to be focussed on non-animal alternatives; how to inform scientists of alternatives to animals; and how to develop and integrate non-animal alternatives. The book is a key document in the development, validation, and use of non-animal methods and is aimed at toxicologists, pharmacologists, and policy-makers in academia, industry and government.

Editors and Affiliations

  • University of Nottingham, UK

    Michael Balls

  • University of Surrey, Guildford, UK

    James Bridges

  • FRAME, Nottingham, UK

    Jacqueline Southee

Bibliographic Information

  • Book Title: Animals and Alternatives in Toxicology

  • Book Subtitle: Present Status and Future Prospects

  • Editors: Michael Balls, James Bridges, Jacqueline Southee

  • DOI: https://doi.org/10.1007/978-1-349-12667-5

  • Publisher: Red Globe Press London

  • eBook Packages: Engineering, Engineering (R0)

  • Copyright Information: FRAME 1991

  • Edition Number: 1

  • Number of Pages: XIII, 390

  • Additional Information: Previously published under the imprint Palgrave

  • Topics: Pharmacology/Toxicology

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