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Stable Isotopes

Applications in Pharmacology, Toxicology and Clinical Research

  • Book
  • © 1978

Overview

Editors:
  1. T. A. Baillie

    1. Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Stable isotopes: scope of application and analytical techniques

    1. Front Matter

      Pages 1-1
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    2. Stable isotopes: essential tools in biological and medical research

      • P. D. Klein, D. L. Hachey, M. J. Kreek, D. A. Schoeller
      Pages 3-14

    3. Mass spectrometric methods of isotope determination

      • J. Throck Watson
      Pages 15-26

    4. Stable isotopes in human drug metabolism studies

      • G. H. Draffan
      Pages 27-42

  3. Applications in pharmacology and toxicology

    1. Front Matter

      Pages 43-43
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    2. Applications of deuterium labelling in pharmacokinetic and concentration-effect studies of clonidine

      • D. S. Davies, E. Neill, J. L. Reid
      Pages 45-54

    3. Isotope effects on pathways of metabolism

      • M. G. Horning, K. Lertratanangkoon, K. D. Haegele, K. Brendel
      Pages 55-64

    4. Use of stable-isotope-labelled compounds in pharmaceutical research

      • W. J. A. VandenHeuvel
      Pages 65-84

    5. The use of deuterium labelling in mechanistic studies of metabolic activation

      • M. Jarman, P. B. Farmer, A. B. Foster, P. J. Cox
      Pages 85-95

    6. The quantitation by gas chromatography-chemical ionisation-mass spectrometry of cyclophosphamide, phosphoramide mustard and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy

      • I. Jardine, C. Fenselau, M. Appler, M.-N. Kan, R. B. Brundrett, M. Colvin
      Pages 97-106

    7. Pharmacokinetics of pethidine and norpethidine in the rat: an application of selected ion monitoring using deuterated internal standards

      • C. Lindberg, C. Bogentoft, B. Dahlström, L. Paalzow
      Pages 107-112

    8. Drug metabolism and pharmacokinetic studies in man utilising nitrogen-15- and deuterium-labelled drugs: the metabolic fate of cinoxacin and the metabolism and pharmacokinetics of propoxyphene

      • R. L. Wolen, B. D. Obermeyer, E. A. Ziege, H. R. Black, C. M. Gruber Jr.
      Pages 113-125

    9. Bioavailability using cold labels: studies on a novel antidiarrhoeal agent SC-27166

      • N. J. Haskins, G. C. Ford, S. J. W. Grigson, R. F. Palmer
      Pages 127-138

    10. The use of stable isotopes to better define toxic metabolic pathways of p-hydroxyacetanilide (acetaminophen) and p-ethoxyacetanilide (phenacetin)

      • S. D. Nelson, W. A. Garland, J. R. Mitchell, Y. Vaishnev, C. N. Statham, A. R. Buckpitt
      Pages 139-147

    11. A new method for the investigation of inter-individual differences in drug metabolism

      • J. D. Baty, P. R. Robinson
      Pages 149-155

    12. Discrimination between endogenous and exogenous testosterone in human plasma after oral treatment with testosterone undecanoate using stable-isotope-labelled compounds and mass spectrometric analyses

      • J. J. de Ridder, P. C. J. M. Koppens
      Pages 157-165

  4. Applications in clinical research

    1. Front Matter

      Pages 167-167
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    2. Application and potential of coenzyme labelling

      • T. Cronholm, T. Curstedt, J. Sjövall
      Pages 169-175

    3. Pathways of steroid metabolism in vivo studied by deuterium labeling techniques

      • T. A. Baillie, R. A. Anderson, M. Axelson, K. Sjövall, J. Sjövall
      Pages 177-188
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Keywords

Editors and Affiliations

  • Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK

    T. A. Baillie

Bibliographic Information

  • Book Title: Stable Isotopes

  • Book Subtitle: Applications in Pharmacology, Toxicology and Clinical Research

  • Editors: T. A. Baillie

  • DOI: https://doi.org/10.1007/978-1-349-03328-7

  • Publisher: Palgrave Macmillan London

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Contributors 1978

  • Softcover ISBN: 978-1-349-03330-0Published: 01 January 1978

  • eBook ISBN: 978-1-349-03328-7Published: 17 June 1978

  • Edition Number: 1

  • Number of Pages: XIII, 314

  • Topics: Pharmacology/Toxicology, Imaging / Radiology

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